Abstract

This article provides a comprehensive overview of n-Tert-Butyl-α-Phenyl Nitrone, a chemical compound with the formula C11H15NO and CID 638877. The article delves into the chemical structure, properties, synthesis, applications, and safety considerations associated with this compound. It aims to provide a detailed understanding of n-Tert-Butyl-α-Phenyl Nitrone, its significance in various fields, and its potential risks.

Introduction to n-Tert-Butyl-α-Phenyl Nitrone

n-Tert-Butyl-α-Phenyl Nitrone is a synthetic organic compound that belongs to the class of nitrone derivatives. It is characterized by its chemical formula C11H15NO and CID 638877. This compound is widely used in various scientific and industrial applications due to its unique properties and reactivity. In this article, we will explore the different aspects of n-Tert-Butyl-α-Phenyl Nitrone, including its chemical structure, properties, synthesis, applications, and safety considerations.

Chemical Structure and Properties

The chemical structure of n-Tert-Butyl-α-Phenyl Nitrone consists of a nitrone group (R2C=NR) attached to a phenyl ring, with a tert-butyl group (C(CH3)3) substituting the nitrogen atom. This structure contributes to its unique properties, such as its ability to act as a spin trap and its reactivity towards free radicals. The nitrone group is highly reactive and can readily react with free radicals, making it a valuable tool in the study of free radical chemistry.

The physical properties of n-Tert-Butyl-α-Phenyl Nitrone include a melting point of approximately 60-62°C and a boiling point of around 300°C. It is a colorless to pale yellow solid that is soluble in organic solvents such as chloroform, acetone, and dimethyl sulfoxide (DMSO). These properties make it convenient for handling and use in various laboratory settings.

Synthesis of n-Tert-Butyl-α-Phenyl Nitrone

The synthesis of n-Tert-Butyl-α-Phenyl Nitrone involves a multi-step process that typically starts with the preparation of the corresponding aldehyde or ketone. The aldehyde or ketone is then converted into the nitrone by reacting it with a nitrating agent, such as nitric acid or nitrous acid. The resulting nitrone is then reduced to obtain n-Tert-Butyl-α-Phenyl Nitrone.

One common synthesis method involves the reaction of 4-methylbenzaldehyde with sodium nitrite in the presence of hydrochloric acid to form the nitrone intermediate. Subsequent reduction of the nitrone using sodium borohydride or lithium aluminum hydride yields the desired compound. This synthesis route is efficient and yields high purity n-Tert-Butyl-α-Phenyl Nitrone.

Applications of n-Tert-Butyl-α-Phenyl Nitrone

n-Tert-Butyl-α-Phenyl Nitrone finds extensive applications in various fields, primarily due to its ability to capture and stabilize free radicals. Here are some of the key applications:

1. **Free Radical Chemistry**: n-Tert-Butyl-α-Phenyl Nitrone is widely used as a spin trap in the study of free radicals. It reacts with free radicals to form stable nitroxide radicals, which can be detected using electron spin resonance (ESR) spectroscopy.

2. **Biological Research**: In biological systems, free radicals play a crucial role in various physiological processes. n-Tert-Butyl-α-Phenyl Nitrone is used to investigate the role of free radicals in cellular signaling, oxidative stress, and inflammation.

3. **Materials Science**: The compound is also employed in the study of polymerization reactions, where it helps in understanding the role of free radicals in the formation of polymer networks.

Safety Considerations

While n-Tert-Butyl-α-Phenyl Nitrone is a valuable tool in scientific research, it is important to handle it with care due to its potential hazards. The compound is considered toxic and can cause irritation to the skin, eyes, and respiratory system. It is also flammable and should be stored in a cool, dry place away from incompatible materials.

Proper safety measures, such as wearing protective gloves and goggles, and ensuring adequate ventilation, are essential when working with n-Tert-Butyl-α-Phenyl Nitrone. Additionally, it is crucial to follow the guidelines provided by the manufacturer and local regulations regarding the handling and disposal of the compound.

Conclusion

n-Tert-Butyl-α-Phenyl Nitrone, with its chemical formula C11H15NO and CID 638877, is a versatile compound with significant applications in free radical chemistry, biological research, and materials science. Its unique structure and properties make it an invaluable tool for scientists and researchers. However, it is important to handle this compound with caution due to its potential hazards. This article has provided a comprehensive overview of n-Tert-Butyl-α-Phenyl Nitrone, covering its chemical structure, properties, synthesis, applications, and safety considerations.

Keywords: n-Tert-Butyl-α-Phenyl Nitrone, C11H15NO, CID 638877, free radicals, spin trap, biological research, materials science, safety considerations.