Abstract

This article provides an in-depth overview of O-Carbomethoxybenzyl Sulfonamide (CAS 112941-26-1), a compound of significant interest to researchers in various scientific fields. The article delves into the chemical properties, synthesis methods, applications, safety considerations, and regulatory aspects of this compound, offering valuable insights for scientists and researchers working with this molecule.

Introduction to O-Carbomethoxybenzyl Sulfonamide

O-Carbomethoxybenzyl Sulfonamide, with the chemical formula C₁₀H₉NO₄S, is a sulfonamide derivative that has garnered attention due to its potential applications in pharmaceuticals, agrochemicals, and organic synthesis. This compound is characterized by the presence of a sulfonamide group attached to a benzyl ring, which is further substituted with a carbomethoxy group. Its unique structure and properties make it a valuable tool in the research laboratory.

Chemical Properties

O-Carbomethoxybenzyl Sulfonamide is a white to off-white crystalline solid that is soluble in organic solvents such as ethanol, acetone, and dimethyl sulfoxide (DMSO). It has a melting point of approximately 150-152°C and a boiling point of around 400°C. The compound is stable under normal storage conditions but may degrade upon exposure to light and heat. Its molecular weight is 253.27 g/mol, and it has a molecular formula of C₁₀H₉NO₄S.

Synthesis Methods

The synthesis of O-Carbomethoxybenzyl Sulfonamide can be achieved through various methods, including the reaction of 4-methoxybenzyl alcohol with chlorosulfonic acid followed by neutralization with sodium hydroxide. Another approach involves the reaction of 4-methoxybenzyl alcohol with thiourea in the presence of a catalyst. These methods require careful control of reaction conditions to ensure the desired product is obtained with high purity.

Applications

O-Carbomethoxybenzyl Sulfonamide finds applications in the pharmaceutical industry as a starting material for the synthesis of various drugs. It is also used in agrochemicals for the development of herbicides and insecticides. Additionally, the compound is valuable in organic synthesis for the construction of complex molecules, including heterocyclic compounds and pharmaceutical intermediates.

Safety Considerations

As with any chemical compound, safety is a critical concern when working with O-Carbomethoxybenzyl Sulfonamide. The compound is considered hazardous and should be handled with appropriate precautions. It is classified as a skin and eye irritant, and inhalation of its dust or fumes can cause respiratory irritation. Researchers should wear protective equipment, such as gloves, goggles, and lab coats, when handling this compound. Proper ventilation and adherence to safety protocols are essential to minimize the risk of exposure.

Regulatory Aspects

The production, import, and export of O-Carbomethoxybenzyl Sulfonamide are subject to regulatory controls. Researchers and manufacturers must comply with the regulations set forth by international and national agencies, such as the United Nations and the Environmental Protection Agency (EPA) in the United States. These regulations ensure the safe and responsible use of the compound and protect human health and the environment.

Conclusion

O-Carbomethoxybenzyl Sulfonamide (CAS 112941-26-1) is a versatile compound with significant potential in various scientific fields. Its unique chemical properties, synthesis methods, and applications make it an essential tool for researchers. Understanding the safety considerations and regulatory aspects associated with this compound is crucial for its proper use. By providing a comprehensive overview of O-Carbomethoxybenzyl Sulfonamide, this article aims to serve as a valuable resource for scientists and researchers working with this molecule.

Keywords

O-Carbomethoxybenzyl Sulfonamide, CAS 112941-26-1, chemical properties, synthesis methods, applications, safety considerations, regulatory aspects, pharmaceuticals, agrochemicals, organic synthesis.