This article provides an in-depth overview of Menadione Sodium Bisulfite, a compound with the CAS number 130-37-0. It explores its chemical properties, applications, safety considerations, and regulatory status, offering a comprehensive guide to understanding this compound's role in various industries and its importance in scientific research.
Menadione Sodium Bisulfite, also known as vitamin K3, is a synthetic form of vitamin K. It is a yellow to orange crystalline powder that is widely used in the pharmaceutical, agricultural, and food industries. This compound plays a crucial role in the activation of certain proteins involved in blood clotting and bone metabolism. In this article, we will delve into the various aspects of Menadione Sodium Bisulfite, including its chemical structure, synthesis, applications, safety profile, and regulatory aspects.
Menadione Sodium Bisulfite has a molecular formula of C19H16Na2O6S2 and a molecular weight of 416.36 g/mol. It is a derivative of vitamin K, which is essential for the synthesis of clotting factors in the liver. The compound is characterized by its yellow to orange crystalline powder form and is soluble in water, alcohol, and chloroform. Its chemical structure consists of a 1,4-naphthoquinone core with a sodium bisulfite group attached to one of the rings.
The synthesis of Menadione Sodium Bisulfite involves several steps, including the oxidation of 2-methyl-1,4-naphthoquinone with sodium hypochlorite to form 2-methyl-1,4-naphthoquinone-7-sulfonic acid. This intermediate is then neutralized with sodium hydroxide to produce 2-methyl-1,4-naphthoquinone-7-sulfonic acid sodium salt. Finally, the sodium salt is treated with sodium bisulfite to yield Menadione Sodium Bisulfite. The process requires careful control of reaction conditions to ensure the desired product is obtained.
Menadione Sodium Bisulfite has a wide range of applications across different industries. In the pharmaceutical industry, it is used as a vitamin K supplement in the treatment of vitamin K deficiency, which can lead to bleeding disorders. It is also used in the production of vitamin K3 preparations for intravenous injection. In agriculture, the compound is used as a feed additive to prevent vitamin K deficiency in livestock. Additionally, it is employed in the food industry as a preservative and antioxidant.
While Menadione Sodium Bisulfite is generally considered safe for use in the recommended doses, it is important to be aware of potential side effects and adverse reactions. High doses of the compound can cause hemolytic anemia, liver damage, and other health issues. It is also contraindicated in individuals with a known hypersensitivity to vitamin K derivatives. As with any medication or supplement, it is essential to follow the prescribed dosage and consult with a healthcare professional before use.
The regulatory status of Menadione Sodium Bisulfite varies by country. In the United States, the compound is approved by the U.S. Food and Drug Administration (FDA) for use in certain veterinary applications. The European Union has also approved its use in animal feed. However, it is important to note that the compound is not approved for human consumption in some countries, and its use is strictly regulated in others.
Menadione Sodium Bisulfite, with the CAS number 130-37-0, is a versatile compound with significant applications in various industries. Its role in blood clotting and bone metabolism makes it an essential component in pharmaceuticals and veterinary medicine. While it is generally safe for use in recommended doses, caution should be exercised to avoid potential side effects. Understanding the chemical properties, synthesis, applications, safety considerations, and regulatory status of Menadione Sodium Bisulfite is crucial for its proper use and regulation.
Menadione Sodium Bisulfite, CAS 130-37-0, vitamin K3, blood clotting, bone metabolism, pharmaceuticals, agriculture, food industry, safety, regulation
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