This article provides a comprehensive breakdown of CAS 829-85-6 Diphenylphosphine, a chemical compound with significant properties and applications in various fields. The article delves into the physical and chemical properties of Diphenylphosphine, its synthesis methods, and its applications in organic synthesis, pharmaceuticals, and materials science. It also discusses the safety and handling considerations associated with this compound, highlighting its importance in modern chemical research and industrial processes.
CAS 829-85-6 Diphenylphosphine, also known as diphenylphosphine oxide, is a colorless liquid with a sweet, fishy odor. It is a versatile chemical compound widely used in organic synthesis due to its ability to act as a nucleophile and a ligand. This article aims to explore the various aspects of Diphenylphosphine, including its properties, synthesis, and applications.
Diphenylphosphine has a molecular formula of C12H11OP and a molecular weight of 197.21 g/mol. It is a non-flammable, colorless liquid with a boiling point of 170°C and a melting point of -35°C. The compound is soluble in organic solvents such as ether, chloroform, and benzene but is insoluble in water. Diphenylphosphine is also a strong nucleophile and can readily react with electrophiles, making it a valuable reagent in organic synthesis.
Diphenylphosphine can be synthesized through various methods, including the reaction of phenylphosphine with phenol, the reaction of phenylphosphine oxide with phenol, and the reduction of diphenylphosphine oxide with lithium aluminum hydride. Each method has its advantages and limitations, and the choice of synthesis route depends on the desired purity and scale of production.
Diphenylphosphine is extensively used in organic synthesis due to its nucleophilic and ligand properties. It is employed in the synthesis of various organic compounds, including heterocycles, phosphorus-containing compounds, and organophosphorus compounds. Some of the key applications include the synthesis of pharmaceuticals, agrochemicals, and fine chemicals.
In the pharmaceutical industry, Diphenylphosphine plays a crucial role in the synthesis of active pharmaceutical ingredients (APIs). It is used in the synthesis of various drugs, including antiviral agents, analgesics, and cardiovascular drugs. The compound's ability to form stable phosphorus-containing bonds makes it an essential reagent in the development of new drugs.
Diphenylphosphine also finds applications in materials science, particularly in the synthesis of organophosphorus materials. These materials are used in various applications, including flame retardants, lubricants, and adhesives. The compound's ability to form covalent bonds with other molecules allows for the creation of novel materials with unique properties.
Diphenylphosphine is a hazardous compound that requires proper handling and storage. It is toxic by inhalation and can cause irritation to the eyes, skin, and respiratory system. Therefore, it is essential to use appropriate personal protective equipment (PPE) when working with this compound. Proper ventilation and adherence to safety protocols are also crucial to prevent accidents and ensure the safety of workers.
CAS 829-85-6 Diphenylphosphine is a versatile chemical compound with significant properties and applications in various fields. Its physical and chemical properties, synthesis methods, and applications in organic synthesis, pharmaceuticals, and materials science make it an essential reagent in modern chemical research and industrial processes. Despite its hazards, proper handling and safety measures can mitigate risks associated with its use.
CAS 829-85-6 Diphenylphosphine, properties, applications, organic synthesis, pharmaceuticals, materials science, safety, handling
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