Abstract

This article provides a comprehensive guide to N-Boc-Ethylenediamine CAS 57260-73-8, an essential compound in the field of organic chemistry. It delves into the properties, synthesis, applications, and safety considerations of this compound, making it a valuable resource for aspiring chemists and researchers.

Introduction to N-Boc-Ethylenediamine CAS 57260-73-8

N-Boc-Ethylenediamine, with the chemical formula C8H18N2O4, is a derivative of ethylenediamine that has been protected with a tert-butyloxycarbonyl (Boc) group. This compound is widely used in organic synthesis due to its versatility and reactivity. Its CAS number, 57260-73-8, is a unique identifier used in chemical databases and research publications.

Properties of N-Boc-Ethylenediamine

N-Boc-Ethylenediamine is a white solid that is soluble in organic solvents such as dichloromethane and dimethylformamide. It has a melting point of approximately 120-122°C and a boiling point of around 312-314°C. The compound is stable under normal conditions but can be sensitive to moisture and heat. Its molecular weight is 206.24 g/mol, and it contains two primary amines that can participate in various chemical reactions.

Synthesis of N-Boc-Ethylenediamine

The synthesis of N-Boc-Ethylenediamine typically involves the protection of the primary amines of ethylenediamine with Boc groups. This can be achieved through a reaction with Boc anhydride or Boc chloride in the presence of a base such as triethylamine. The reaction is usually carried out in an organic solvent, and the protected compound is then purified through recrystallization or column chromatography.

Applications of N-Boc-Ethylenediamine

N-Boc-Ethylenediamine finds applications in the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and fine chemicals. It is used as a building block in the construction of heterocyclic compounds, such as pyrimidines and purines, which are essential components of nucleic acids. Additionally, it is employed in the synthesis of chelating agents, which are used for metal ion sequestration.

Chemical Reactions Involving N-Boc-Ethylenediamine

The primary amines in N-Boc-Ethylenediamine can undergo a variety of chemical reactions, including nucleophilic substitution, condensation, and cyclization reactions. The Boc group can be selectively removed under controlled conditions, allowing for the introduction of various functional groups. This versatility makes N-Boc-Ethylenediamine a valuable reagent in organic synthesis.

Safety Considerations

Handling N-Boc-Ethylenediamine requires appropriate safety measures due to its potential hazards. The compound is irritant to the skin, eyes, and respiratory system. It should be handled with gloves, safety goggles, and a fume hood. In case of accidental exposure, immediate medical attention should be sought. Proper storage in a cool, dry place away from incompatible materials is also crucial.

Conclusion

N-Boc-Ethylenediamine CAS 57260-73-8 is a crucial compound in organic chemistry, offering a wide range of synthetic applications. Its properties, synthesis methods, and safety considerations are essential knowledge for aspiring chemists and researchers. Understanding the intricacies of this compound can greatly enhance the efficiency and success of organic synthesis endeavors.

Keywords: N-Boc-Ethylenediamine, CAS 57260-73-8, organic synthesis, ethylenediamine, Boc protection, chemical reactions, safety considerations