Abstract

This article provides a comprehensive guide to 5-Chloro-8-hydroxyquinoline, also known as CAS 130-16-5. It delves into the chemical properties, synthesis methods, applications, safety considerations, and environmental impact of this compound. By exploring these aspects, the article aims to unlock the secrets behind this versatile chemical, offering valuable insights for researchers, chemists, and those in related fields.

Introduction to 5-Chloro-8-hydroxyquinoline (CAS 130-16-5)

5-Chloro-8-hydroxyquinoline, with the chemical formula C9H6ClNO, is a type of heterocyclic compound belonging to the quinoline family. It is characterized by a benzene ring fused with a pyridine ring, with a chlorine atom and a hydroxyl group attached to the pyridine ring. This compound has been widely used in various industries due to its unique properties and applications.

Chemical Properties

The chemical properties of 5-Chloro-8-hydroxyquinoline are influenced by its molecular structure. It is a white crystalline solid with a melting point of approximately 237°C. The compound is slightly soluble in water and more soluble in organic solvents such as ethanol, acetone, and chloroform. It also exhibits a characteristic yellow color when dissolved in alkaline solutions.

Synthesis Methods

The synthesis of 5-Chloro-8-hydroxyquinoline can be achieved through various methods, including the Knoevenagel condensation, the Stille coupling reaction, and the Pictet-Spengler reaction. Each method involves the reaction of specific starting materials to form the desired compound. The choice of synthesis method depends on factors such as the desired purity, yield, and cost-effectiveness.

Applications

5-Chloro-8-hydroxyquinoline finds applications in several industries. It is used as a corrosion inhibitor in water treatment, a fungicide in agriculture, and a dye intermediate in the textile industry. Additionally, it serves as a precursor for the synthesis of other compounds, such as 8-hydroxyquinoline, which is used in the production of pharmaceuticals and dyes.

Safety Considerations

Handling 5-Chloro-8-hydroxyquinoline requires caution due to its potential health hazards. The compound is toxic if ingested, inhaled, or absorbed through the skin. It can cause irritation to the eyes, skin, and respiratory system. Therefore, appropriate safety measures, such as wearing protective gloves, goggles, and a mask, should be taken when working with this chemical.

Environmental Impact

The environmental impact of 5-Chloro-8-hydroxyquinoline is a concern due to its potential persistence and bioaccumulation in the environment. It is classified as a hazardous substance, and its release into the environment should be minimized. Proper waste disposal and adherence to environmental regulations are essential to mitigate the negative impact on ecosystems.

Conclusion

In conclusion, 5-Chloro-8-hydroxyquinoline, with its unique chemical properties and diverse applications, is a significant compound in various industries. This comprehensive guide has explored the synthesis methods, applications, safety considerations, and environmental impact of this compound. By understanding these aspects, researchers, chemists, and industry professionals can make informed decisions regarding the use and handling of 5-Chloro-8-hydroxyquinoline.

Keywords: 5-Chloro-8-hydroxyquinoline, CAS 130-16-5, chemical properties, synthesis methods, applications, safety considerations, environmental impact