Abstract

This comprehensive guide delves into the mysteries of 1-hexyl-pyrrolidin-2-one, a chemical compound with the CAS number 4838-65-7. The article explores its chemical properties, synthesis methods, applications, safety considerations, and regulatory aspects, providing a thorough understanding of this compound's role in various industries.

Introduction to 1-Hexyl-Pyrrolidin-2-One

1-hexyl-pyrrolidin-2-one, also known as hexylpyrrolidone, is a cyclic amine derivative that has gained significant attention in the chemical industry. It is a colorless, volatile liquid with a characteristic odor. This compound is widely used as a solvent, surfactant, and fragrance ingredient in various applications. Understanding its properties and uses is crucial for those involved in its production, distribution, and utilization.

Chemical Properties of 1-Hexyl-Pyrrolidin-2-One

1-hexyl-pyrrolidin-2-one has a molecular formula of C7H15NO and a molecular weight of 129.21 g/mol. It is a secondary amine with a pyrrolidine ring. The compound is soluble in water, alcohol, and most organic solvents. Its boiling point is 244°C, and it has a melting point of -45°C. These properties make it suitable for use in a wide range of applications, including pharmaceuticals, cosmetics, and industrial processes.

Synthesis of 1-Hexyl-Pyrrolidin-2-One

The synthesis of 1-hexyl-pyrrolidin-2-one involves the reaction of hexylamine with formaldehyde in the presence of a catalyst. This process is known as the Mannich reaction. The reaction conditions, such as temperature, pressure, and catalyst choice, can significantly affect the yield and purity of the final product. Additionally, alternative synthesis methods, such as the Knoevenagel condensation, have also been explored to produce 1-hexyl-pyrrolidin-2-one.

Applications of 1-Hexyl-Pyrrolidin-2-One

1-hexyl-pyrrolidin-2-one finds extensive use in various industries. In the pharmaceutical sector, it is used as a solvent for injectable drugs and as a component in nasal sprays. In the cosmetic industry, it serves as a solvent and fragrance ingredient in perfumes and personal care products. Moreover, it is employed as a solvent in the production of inks, adhesives, and coatings.

Safety Considerations for 1-Hexyl-Pyrrolidin-2-One

While 1-hexyl-pyrrolidin-2-one is widely used, it is important to consider its safety profile. The compound is considered moderately toxic and can cause irritation to the skin, eyes, and respiratory system. Proper handling and storage procedures are essential to minimize exposure. Safety data sheets (SDS) should be consulted for detailed information on handling and emergency response measures.

Regulatory Aspects of 1-Hexyl-Pyrrolidin-2-One

The production, distribution, and use of 1-hexyl-pyrrolidin-2-one are subject to various regulations. These regulations vary by country and are designed to protect human health and the environment. Compliance with these regulations is crucial for businesses involved in the handling of this compound. Regular updates on regulatory changes are necessary to ensure ongoing compliance.

Conclusion

Unlocking the secrets of 1-hexyl-pyrrolidin-2-one, CAS 4838-65-7, provides a comprehensive understanding of this versatile chemical compound. From its chemical properties and synthesis methods to its applications and safety considerations, this guide offers valuable insights for professionals in the chemical industry. By adhering to regulatory standards and prioritizing safety, the responsible use of 1-hexyl-pyrrolidin-2-one can continue to contribute to various industries.

Keywords: 1-hexyl-pyrrolidin-2-one, CAS 4838-65-7, chemical properties, synthesis, applications, safety, regulatory aspects