ChemDibenzocyclooctyne N-Hydroxysuccinimide Ester: Comprehensive Guide & Detailed Product Information for Researchers

March 20, 2025

Abstract

This article provides a comprehensive guide and detailed product information for researchers about ChemDibenzocyclooctyne N-Hydroxysuccinimide Ester. It covers various aspects such as product parameters, usage scenarios, case studies, and solutions to common issues faced by researchers.

Table of Contents

Product Parameters

ChemDibenzocyclooctyne N-Hydroxysuccinimide Ester is a versatile reagent used in various chemical reactions. The following table provides detailed information about its parameters:

Parameter Value
Chemical Formula C14H10N2O4
Molecular Weight 254.23 g/mol
Appearance White to off-white crystalline powder
Solubility Soluble in DMSO, DMF, and other organic solvents

Usage Scenarios

ChemDibenzocyclooctyne N-Hydroxysuccinimide Ester finds applications in various research fields, including organic synthesis, medicinal chemistry, and material science. Here are some common usage scenarios:

  • Organic Synthesis: It is used as a coupling agent in the formation of carbon-carbon bonds, such as the Staudinger reaction and the Negishi coupling.
  • Medicinal Chemistry: It is employed in the synthesis of bioactive molecules, including peptides, peptidomimetics, and small molecules.
  • Material Science: It is used in the synthesis of novel materials, such as polymers and organometallic compounds.

Case Studies

Here are two real-life case studies showcasing the application of ChemDibenzocyclooctyne N-Hydroxysuccinimide Ester in research:

  • Case Study 1: A research team from a renowned university used this reagent to synthesize a novel peptide with potential therapeutic applications. The team successfully coupled the peptide with a fluorescent dye using the Staudinger reaction, which was facilitated by ChemDibenzocyclooctyne N-Hydroxysuccinimide Ester.
  • Case Study 2: Another research group employed this reagent in the synthesis of a small molecule with anti-cancer properties. The team utilized the Negishi coupling reaction to construct the core structure of the molecule, with ChemDibenzocyclooctyne N-Hydroxysuccinimide Ester acting as the coupling agent.

Solutions

While using ChemDibenzocyclooctyne N-Hydroxysuccinimide Ester, researchers may encounter certain challenges. Here are some common issues and their solutions:

  • Problem: Insufficient yield in the reaction.
  • Solution: Optimize the reaction conditions, such as temperature, solvent, and catalyst concentration.
  • Problem: Difficulty in purifying the product.
  • Solution: Employ advanced purification techniques, such as column chromatography or preparative HPLC.
  • Problem: Unreactive substrate.
  • Solution: Modify the substrate structure or explore alternative coupling agents.

Summary

ChemDibenzocyclooctyne N-Hydroxysuccinimide Ester is a valuable reagent in the field of research. Its versatile nature, coupled with its ability to facilitate various chemical reactions, makes it an indispensable tool for scientists. This article has provided a comprehensive guide and detailed product information, covering product parameters, usage scenarios, case studies, and solutions to common issues. Researchers can benefit from this information to optimize their experiments and achieve successful outcomes.

Keywords

ChemDibenzocyclooctyne N-Hydroxysuccinimide Ester, product parameters, usage scenarios, case studies, solutions, organic synthesis, medicinal chemistry, material science

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