Abstract

This article provides a comprehensive overview of Octocrylene, a chemical compound with the CAS number 6197-30-4. Octocrylene is widely used in the cosmetic industry as a UV filter to protect skin from harmful ultraviolet radiation. The article delves into the chemical properties, synthesis methods, applications, safety concerns, regulatory status, and environmental impact of Octocrylene, offering a detailed insight into its role in the skincare industry.

Introduction to Octocrylene

Octocrylene, with the Chemical Abstracts Service (CAS) number 6197-30-4, is a chemical compound that has gained significant attention in the cosmetic industry. It is primarily used as a UV filter in sunscreens and skincare products to shield the skin from the damaging effects of ultraviolet (UV) radiation. This article aims to explore the various aspects of Octocrylene, including its chemical properties, synthesis, applications, safety, and environmental considerations.

Chemical Properties of Octocrylene

Octocrylene is a white to off-white crystalline solid that is odorless and stable under normal conditions. It has a molecular formula of C24H30O and a molecular weight of 338.47 g/mol. The compound contains a benzophenone ring, which is responsible for its UV-filtering properties. Octocrylene is soluble in organic solvents such as acetone, ethanol, and hexane but is insoluble in water. Its melting point is approximately 67-69°C, and it has a boiling point of around 410°C.

Synthesis of Octocrylene

The synthesis of Octocrylene involves a multi-step process that typically starts with the reaction of 2,4-dichlorobenzophenone with 2,4-dichloro-1,3-dioxolane in the presence of a base. This reaction yields 2,4-dichloro-5-(2,4-dichlorophenyl)-1,3-dioxolane, which is then cyclized to form Octocrylene. The process requires careful control of reaction conditions to ensure the desired product is obtained. The overall yield of the synthesis process can vary, but it generally ranges from 70% to 80%.

Applications of Octocrylene

Octocrylene is extensively used in the cosmetic industry, particularly in sunscreens and skincare products. Its primary application is as a UVB absorber, which helps to protect the skin from the harmful effects of UVB radiation that can cause sunburn and skin damage. In addition to its UV-filtering properties, Octocrylene also has photostabilizing effects, which means it can protect other UV filters from degradation when exposed to sunlight. This makes it a valuable ingredient in sunscreen formulations.

Safety Concerns and Regulatory Status

Octocrylene has been evaluated for safety by various regulatory agencies, including the U.S. Food and Drug Administration (FDA) and the European Union's Scientific Committee on Consumer Safety (SCCS). The FDA has classified Octocrylene as a Generally Recognized as Safe (GRAS) ingredient for use in cosmetics. The SCCS has also concluded that Octocrylene is safe for use in cosmetic products, provided it is used within the recommended concentration limits.

However, some concerns have been raised regarding the potential for Octocrylene to cause allergic reactions in sensitive individuals. Studies have shown that Octocrylene can be metabolized into benzophenone derivatives, which may have hormonal effects. Despite these concerns, the overall safety profile of Octocrylene remains favorable, and it is widely used in the cosmetic industry.

Environmental Impact of Octocrylene

Octocrylene is considered to be biodegradable, but its breakdown products can still be harmful to marine life. When sunscreen products containing Octocrylene are washed off the skin and enter water bodies, the compound can be released into the environment. Research has indicated that Octocrylene and its breakdown products can accumulate in marine organisms, potentially leading to adverse effects on ecosystems.

Efforts are being made to develop alternative UV filters that are less harmful to the environment. However, until these alternatives become widely available, Octocrylene remains a popular choice in the cosmetic industry due to its effectiveness and safety profile.

Conclusion

Octocrylene, with the CAS number 6197-30-4, is a widely used UV filter in the cosmetic industry. Its chemical properties, synthesis methods, and applications in sunscreens and skincare products have made it a valuable ingredient. While concerns regarding safety and environmental impact exist, the overall safety profile of Octocrylene is favorable, and it continues to be a popular choice among consumers and manufacturers alike.

Keywords: Octocrylene, CAS number 6197-30-4, UV filter, sunscreen, skincare, safety, environmental impact, cosmetic industry.