Abstract

This article provides a comprehensive guide for beginners on 3-Amino-4-Methoxybenzanilide, CAS 120-35-4. It delves into the chemical properties, synthesis methods, applications, safety considerations, and storage guidelines of this compound. By exploring these aspects, the article aims to offer a foundational understanding of 3-Amino-4-Methoxybenzanilide for those new to the field of organic chemistry.

Introduction to 3-Amino-4-Methoxybenzanilide

3-Amino-4-Methoxybenzanilide, with the chemical formula C₈H₉NO₂, is an organic compound belonging to the class of aromatic amines. It is commonly referred to by its CAS number, 120-35-4. This compound is of interest in various fields, including pharmaceuticals, agrochemicals, and materials science. In this guide, we will explore the key aspects of 3-Amino-4-Methoxybenzanilide to help beginners understand its significance and potential applications.

Chemical Properties

3-Amino-4-Methoxybenzanilide is a white to off-white crystalline solid. It has a melting point of approximately 114-116°C and a boiling point of around 300°C. The compound is sparingly soluble in water but more soluble in organic solvents such as ethanol, acetone, and dichloromethane. It is also hygroscopic, meaning it absorbs moisture from the air. These properties make it important to handle 3-Amino-4-Methoxybenzanilide with care, especially in environments with high humidity.

The chemical structure of 3-Amino-4-Methoxybenzanilide consists of a benzene ring with an amino group (-NH₂) attached to the third position and a methoxy group (-OCH₃) attached to the fourth position. This structural arrangement contributes to its reactivity and potential for various chemical transformations.

Synthesis Methods

The synthesis of 3-Amino-4-Methoxybenzanilide can be achieved through several methods, each with its own advantages and limitations. One common synthesis involves the reaction of 4-methoxybenzyl chloride with aniline in the presence of a base, such as sodium hydroxide or potassium hydroxide. This reaction leads to the formation of the desired compound in good yield.

Another method involves the nitration of 4-methoxybenzyl chloride followed by reduction of the resulting nitro compound. This approach requires careful control of reaction conditions to avoid over-reduction or side reactions. Additionally, the synthesis of 3-Amino-4-Methoxybenzanilide can also be achieved through the reaction of 4-methoxybenzyl alcohol with ammonia or an amine derivative.

Applications

3-Amino-4-Methoxybenzanilide finds applications in various industries. In the pharmaceutical sector, it is used as a precursor for the synthesis of active pharmaceutical ingredients (APIs). Its structural features make it suitable for the development of drugs with specific pharmacological properties.

In agrochemicals, 3-Amino-4-Methoxybenzanilide can be used as an intermediate in the synthesis of herbicides and insecticides. Its reactivity allows for the introduction of various functional groups, which can enhance its effectiveness against pests and weeds.

Furthermore, 3-Amino-4-Methoxybenzanilide has potential applications in materials science, where it can be used as a building block for the synthesis of polymers and other organic materials. Its unique properties make it a valuable compound for research and development purposes.

Safety Considerations

Handling 3-Amino-4-Methoxybenzanilide requires adherence to safety guidelines to minimize potential risks. The compound is considered hazardous and can cause irritation to the skin, eyes, and respiratory system. Therefore, it is crucial to wear appropriate personal protective equipment (PPE) when working with this compound.

In addition, 3-Amino-4-Methoxybenzanilide is flammable and should be stored in a cool, well-ventilated area away from sources of ignition. It is also important to ensure proper ventilation when working with this compound to prevent the accumulation of vapors.

Storage Guidelines

Proper storage of 3-Amino-4-Methoxybenzanilide is essential to maintain its stability and prevent degradation. The compound should be stored in a tightly sealed container to prevent moisture absorption and contamination. It is recommended to store 3-Amino-4-Methoxybenzanilide in a cool, dry place at room temperature.

To further ensure safety, it is advisable to store the compound away from incompatible materials, such as strong acids or bases. Additionally, proper labeling of containers and adherence to local regulations regarding the storage of hazardous substances are crucial for maintaining a safe working environment.

Conclusion

In conclusion, 3-Amino-4-Methoxybenzanilide, CAS 120-35-4, is an important compound with diverse applications in various industries. This comprehensive guide for beginners has provided an overview of its chemical properties, synthesis methods, applications, safety considerations, and storage guidelines. Understanding these aspects is crucial for anyone working with this compound, whether in research, development, or industrial settings.

Keywords: 3-Amino-4-Methoxybenzanilide, CAS 120-35-4, chemical properties, synthesis methods, applications, safety considerations, storage guidelines