Abstract

This article provides a comprehensive comparison of 4'-Chloroacetophenone (CAS 99-91-2) with other chemicals, highlighting its unique properties, uses, and potential risks. By examining its physical and chemical characteristics, toxicity, environmental impact, applications, and regulatory status, this side-by-side comparison aims to provide a clearer understanding of 4'-Chloroacetophenone's position within the chemical landscape.

Introduction

4'-Chloroacetophenone, with the CAS number 99-91-2, is a widely used chemical compound in various industries. This article aims to provide a detailed comparison of 4'-Chloroacetophenone with other chemicals, focusing on six key aspects: physical and chemical properties, toxicity, environmental impact, applications, regulatory status, and safety considerations.

Physical and Chemical Properties

4'-Chloroacetophenone is an organic compound with a molecular formula of C8H6ClO. It is a colorless to pale yellow liquid with a pungent, sweet odor. In comparison to other chemicals, such as benzaldehyde or acetophenone, 4'-Chloroacetophenone has a higher boiling point (189°C) and a lower melting point (-15°C). Its molecular weight is 165.57 g/mol, which is slightly higher than that of benzaldehyde (106.12 g/mol) and acetophenone (120.15 g/mol). These differences in physical and chemical properties can influence its handling, storage, and use in various applications.

Toxicity

4'-Chloroacetophenone is considered moderately toxic. It can cause irritation to the eyes, skin, and respiratory system. Ingestion of the compound can lead to severe symptoms, including nausea, vomiting, and central nervous system depression. In comparison, benzaldehyde is highly toxic and can cause severe irritation and damage to the respiratory system, while acetophenone is less toxic but can still cause irritation to the eyes and skin. It is crucial to handle 4'-Chloroacetophenone with appropriate safety measures to minimize potential health risks.

Environmental Impact

4'-Chloroacetophenone is classified as a hazardous chemical due to its potential environmental impact. It is persistent in the environment and can accumulate in aquatic organisms. When released into the environment, it can undergo photodegradation, leading to the formation of chlorinated by-products that are more toxic than the original compound. In contrast, benzaldehyde is volatile and can be broken down in the atmosphere, reducing its persistence. Acetophenone is also volatile but has a lower persistence than 4'-Chloroacetophenone. Environmental regulations and guidelines should be followed to minimize the release of 4'-Chloroacetophenone into the environment.

Applications

4'-Chloroacetophenone finds applications in various industries, including pharmaceuticals, agriculture, and organic synthesis. It is used as a precursor for the synthesis of pharmaceutical intermediates, pesticides, and other chemicals. In comparison, benzaldehyde is primarily used in the production of resins, dyes, and perfumes. Acetophenone is widely used in the synthesis of pharmaceuticals, flavors, and fragrances. The specific applications of each compound depend on their unique chemical properties and reactivity.

Regulatory Status

4'-Chloroacetophenone is subject to regulatory controls in many countries. It is classified as a hazardous substance under various regulations, such as the European Union's Classification, Labelling, and Packaging (CLP) Regulation and the United States' Occupational Safety and Health Administration (OSHA) standards. Compliance with these regulations is essential for the safe handling and use of the compound. Benzaldehyde and acetophenone also have specific regulatory classifications and restrictions, depending on their intended use and the country of operation.

Safety Considerations

When handling 4'-Chloroacetophenone, it is crucial to follow safety guidelines to protect human health and the environment. This includes using appropriate personal protective equipment (PPE), such as gloves, goggles, and respirators. Proper ventilation is also essential to minimize exposure to the compound. In comparison, benzaldehyde and acetophenone require similar safety precautions, although the specific PPE and ventilation requirements may vary slightly.

Conclusion

In conclusion, this article has provided a detailed comparison of 4'-Chloroacetophenone (CAS 99-91-2) with other chemicals, focusing on physical and chemical properties, toxicity, environmental impact, applications, regulatory status, and safety considerations. While 4'-Chloroacetophenone shares some similarities with benzaldehyde and acetophenone, it also has distinct characteristics that make it suitable for specific applications. Understanding these differences is crucial for the safe and responsible use of 4'-Chloroacetophenone and other chemicals in various industries.

Keywords: 4'-Chloroacetophenone, CAS 99-91-2, benzaldehyde, acetophenone, toxicity, environmental impact, applications, regulatory status, safety considerations.