{"id":175,"date":"2024-08-06T01:56:55","date_gmt":"2024-08-06T01:56:55","guid":{"rendered":"https:\/\/chemneo.com\/?post_type=product&p=175"},"modified":"2024-08-06T01:57:23","modified_gmt":"2024-08-06T01:57:23","slug":"levodopa-cas59-92-7","status":"publish","type":"product","link":"https:\/\/chemneo.com\/es\/product\/175.html","title":{"rendered":"Levodopa CAS#59-92-7"},"content":{"rendered":"
\n\n\n\n
Levodopa Chemical Properties<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Melting point<\/td>\n276-278 \u00b0C (lit.)<\/span><\/td>\n<\/tr>\n
Punto de ebullici\u00f3n<\/td>\n334.28\u00b0C (rough estimate)<\/span><\/td>\n<\/tr>\n
alpha<\/td>\n-11.7 \u00ba (c=5.3, 1N HCl)<\/span><\/td>\n<\/tr>\n
densidad<\/td>\n1.3075 (rough estimate)<\/span><\/td>\n<\/tr>\n
\u00edndice de refracci\u00f3n<\/td>\n-12 \u00b0 (C=5, 1mol\/L HCl)<\/span><\/td>\n<\/tr>\n
storage temp.<\/td>\n2-8\u00b0C<\/span><\/td>\n<\/tr>\n
solubility<\/td>\nSlightly soluble in water, practically insoluble in ethanol (96 per cent). It is freely soluble in 1 M hydrochloric acid and sparingly soluble in 0.1 M hydrochloric acid .<\/span><\/td>\n<\/tr>\n
pka<\/td>\n2.32(at 25\u2103)<\/span><\/td>\n<\/tr>\n
formulario<\/td>\nCrystalline Powder<\/span><\/td>\n<\/tr>\n
color<\/td>\nWhite to creamy<\/span><\/td>\n<\/tr>\n
Olor<\/td>\nat 100.00 %. odorless<\/span><\/td>\n<\/tr>\n
Odor Type<\/td>\nodorless<\/span><\/td>\n<\/tr>\n
Water Solubility<\/td>\nSlightly soluble in water, dilute hydrochloric acid and formic acid. Insoluble in ethanol.<\/span><\/td>\n<\/tr>\n
Merck<\/td>\n14,5464<\/span><\/td>\n<\/tr>\n
BRN<\/td>\n2215169<\/span><\/td>\n<\/tr>\n
Estabilidad:<\/td>\nStable. Incompatible with strong oxidizing agents. Light and air sensitive.<\/span><\/td>\n<\/tr>\n
InChIKey<\/td>\nWTDRDQBEARUVNC-LURJTMIESA-N<\/span><\/td>\n<\/tr>\n
LogP<\/td>\n-1.154 (est)<\/span><\/td>\n<\/tr>\n
CAS DataBase Reference<\/td>\n59-92-7(CAS DataBase Reference)<\/a><\/span><\/td>\n<\/tr>\n
NIST Chemistry Reference<\/td>\nLevodopa(59-92-7)<\/a><\/span><\/td>\n<\/tr>\n
Sistema de registro de sustancias de la EPA<\/td>\nLevodopa (59-92-7)<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n\n\n\n\n
<\/td>\n<\/tr>\n
Informaci\u00f3n de seguridad<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n\n
Hazard Codes<\/td>\nXn<\/a><\/span><\/td>\n<\/tr>\n
Risk Statements<\/td>\n22-36\/37\/38-20\/21\/22<\/a><\/span><\/td>\n<\/tr>\n
Safety Statements<\/td>\n26-36-24\/25<\/a><\/span><\/td>\n<\/tr>\n
WGK Germany<\/td>\n3<\/span><\/td>\n<\/tr>\n
RTECS<\/td>\nAY5600000<\/span><\/td>\n<\/tr>\n
F<\/td>\n10-23<\/a><\/span><\/td>\n<\/tr>\n
TSCA<\/td>\nYes<\/span><\/td>\n<\/tr>\n
HS Code<\/td>\n29225090<\/span><\/td>\n<\/tr>\n
Hazardous Substances Data<\/td>\n59-92-7(Hazardous Substances Data)<\/a><\/span><\/td>\n<\/tr>\n
Toxicidad<\/td>\nLD50 in mice (mg\/kg): 3650 \u00b1327 orally, 1140 \u00b166 i.p., 450 \u00b142 i.v., >400 s.c.; in male, female rats (mg\/kg): >3000, >3000 orally; 624, 663 i.p.; >1500, >1500 s.c. (Clark)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>","protected":false},"excerpt":{"rendered":"

La levodopa, tambi\u00e9n conocida como L-DOPA o 3,4-dihidroxi-L-fenilalanina, es un amino\u00e1cido natural y un precursor fundamental en la bios\u00edntesis de los neurotransmisores dopamina, norepinefrina y epinefrina. Con la f\u00f3rmula molecular C9H11NO4, la levodopa es un amino\u00e1cido grande y neutro que desempe\u00f1a un papel importante en el tratamiento de la enfermedad de Parkinson debido a su capacidad para atravesar la barrera hematoencef\u00e1lica y convertirse en dopamina.<\/p>\n

Qu\u00edmicamente, la levodopa se sintetiza a partir del amino\u00e1cido precursor tirosina mediante la acci\u00f3n de la enzima tirosina hidroxilasa. Como medicamento, la levodopa suele formularse con un inhibidor perif\u00e9rico de la DOPA descarboxilasa para reducir su conversi\u00f3n en dopamina fuera del cerebro, aumentando as\u00ed su eficacia y reduciendo los efectos secundarios.<\/p>\n

La levodopa se caracteriza por su eficacia para aliviar los s\u00edntomas motores de la enfermedad de Parkinson, como temblores, rigidez y bradicinesia. Suele administrarse por v\u00eda oral y absorberse en el tracto gastrointestinal, desde donde se transporta al cerebro.<\/p>\n

En resumen, la levodopa es un compuesto farmac\u00e9utico vital utilizado en neurolog\u00eda por su papel en el tratamiento de la enfermedad de Parkinson al reponer los niveles cerebrales de dopamina. Su administraci\u00f3n selectiva y su conversi\u00f3n en dopamina la convierten en una opci\u00f3n de tratamiento esencial para controlar los s\u00edntomas motores asociados a esta enfermedad.<\/p>","protected":false},"featured_media":200,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[18],"product_tag":[19],"class_list":{"0":"post-175","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-petroleum-additives","7":"product_tag-petroleum-additives","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/product\/175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/comments?post=175"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/media\/200"}],"wp:attachment":[{"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/media?parent=175"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/product_brand?post=175"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/product_cat?post=175"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/product_tag?post=175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}