{"id":4102,"date":"2024-08-28T03:05:03","date_gmt":"2024-08-28T03:05:03","guid":{"rendered":"https:\/\/chemneo.com\/?post_type=product&p=4102"},"modified":"2024-08-28T03:06:16","modified_gmt":"2024-08-28T03:06:16","slug":"huperzine-a-cas-102518-79-6","status":"publish","type":"product","link":"https:\/\/chemneo.com\/es\/product\/4102.html","title":{"rendered":"Huperzina A CAS# 102518-79-6"},"content":{"rendered":"

Huperzina A CAS# 102518-79-6<\/p>\n

\n\n\n\n\n
(-)-Huperzine A Basic information<\/td>\n<\/tr>\n
Huperzia serrata extract\u00a0Indications\u00a0Side effects\u00a0Inhibition\u00a0Uses<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n
Product Name:<\/td>\n(-)-Huperzine A<\/td>\n<\/tr>\n
Synonyms:<\/td>\nHuperzine-A1-5%<\/span>;(5r-(5-alpha,9-beta,11e))-ydro-7-methyl<\/span>;5,9-methanocycloocta(b)pyridin-2(1h)-one,5-amino-11-ethylidene-5,6,9,10-tetrah<\/span>;HUPERIZINE<\/span>;(-)-HUPERZINE A FROM HUPERZIA SERRATA<\/span>;HuperziaSerrateP.E120786-18-7\/<\/span>;(5R,9R,E)-5-AMino-11-ethylidene-7-Methyl-5,6,9,10-tetrahydro-5,9-Methanocycloocta[b]pyridin-2(1H)-one<\/span>;(-)-Huperzine A (HupA)<\/span><\/td>\n<\/tr>\n
CAS:<\/td>\n102518-79-6<\/b><\/td>\n<\/tr>\n
MF:<\/td>\nC15H18N2O<\/td>\n<\/tr>\n
MW:<\/td>\n242.32<\/td>\n<\/tr>\n
EINECS:<\/td>\n600-320-6<\/td>\n<\/tr>\n
Product Categories:<\/td>\nInhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Nutritional Ingredients;reference substance;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;API;Alkaloids;102518-79-6<\/td>\n<\/tr>\n
Mol File:<\/td>\n102518-79-6.mol<\/td>\n<\/tr>\n
\"(-)-Huperzine<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n\n\n\n\n
<\/td>\n<\/tr>\n
(-)-Huperzine A Chemical Properties<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Melting point<\/td>\n211-216oC<\/span><\/td>\n<\/tr>\n
alpha<\/td>\nD -147\u00b0 (c = 0.36 in CH3OH) (Ayer); D24.5 -150.4\u00b0 (c = 0.498 in MeOH) (Liu)<\/span><\/td>\n<\/tr>\n
Punto de ebullici\u00f3n<\/td>\n505.0\u00b150.0 \u00b0C(Predicted)<\/span><\/td>\n<\/tr>\n
densidad<\/td>\n1.20\u00b10.1 g\/cm3(Predicted)<\/span><\/td>\n<\/tr>\n
storage temp.<\/td>\nKeep in dark place,Inert atmosphere,2-8\u00b0C<\/span><\/td>\n<\/tr>\n
solubility<\/td>\ninsoluble in H2O; \u226512.12 mg\/mL in DMSO; \u226523.13 mg\/mL in EtOH<\/span><\/td>\n<\/tr>\n
pka<\/td>\n12.25\u00b10.60(Predicted)<\/span><\/td>\n<\/tr>\n
formulario<\/td>\nSolid<\/span><\/td>\n<\/tr>\n
color<\/td>\nWhite to Almost white<\/span><\/td>\n<\/tr>\n
optical activity<\/td>\n[\u03b1]\/D -153\u00b15\u00b0, c = 0.5 in methanol<\/span><\/td>\n<\/tr>\n
InChI<\/td>\nInChI=1S\/C15H18N2O\/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10\/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)\/b11-3+\/t10-,15+\/m0\/s1<\/span><\/td>\n<\/tr>\n
InChIKey<\/td>\nZRJBHWIHUMBLCN-YQEJDHNASA-N<\/span><\/td>\n<\/tr>\n
SMILES<\/td>\nC12C[C@@]3([H])\/C(=CC)\/[C@@](N)(C=1C=CC(=O)N2)CC(C)=C3<\/span><\/td>\n<\/tr>\n
LogP<\/td>\n0.833 (est)<\/span><\/td>\n<\/tr>\n
CAS DataBase Reference<\/td>\n102518-79-6(CAS DataBase Reference)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n\n\n\n\n
<\/td>\n<\/tr>\n
Informaci\u00f3n de seguridad<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n
Hazard Codes<\/td>\nT+<\/span><\/td>\n<\/tr>\n
Risk Statements<\/td>\n26\/27\/28-36\/37\/38<\/span><\/td>\n<\/tr>\n
Safety Statements<\/td>\n26-36\/37\/39-45<\/span><\/td>\n<\/tr>\n
RIDADR<\/td>\nUN 1544 6.1\/PG 2<\/span><\/td>\n<\/tr>\n
WGK Germany<\/td>\n3<\/span><\/td>\n<\/tr>\n
RTECS<\/td>\nPB9185700<\/span><\/td>\n<\/tr>\n
HS Code<\/td>\n29339900<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

 <\/p>","protected":false},"excerpt":{"rendered":"

La huperzina A es un extracto natural de plantas. En comparaci\u00f3n con otros medicamentos similares para el tratamiento de la EA aprobados por la FDA estadounidense, la huperzina A tiene una estructura qu\u00edmica \u00fanica y una selectividad extremadamente alta para inhibir la acetilcolinesterasa en el cerebro y mejorar la funci\u00f3n colin\u00e9rgica de las neuronas. Adem\u00e1s, la huperzina A tiene efectos evidentes en la mejora de la memoria y la capacidad cognitiva.<\/p>\n

La huperzina A tiene un peso molecular relativo peque\u00f1o, alta solubilidad en l\u00edpidos y es f\u00e1cil de atravesar la barrera hematoencef\u00e1lica. Tras entrar en el sistema nervioso central, se distribuye principalmente en el l\u00f3bulo frontal, el l\u00f3bulo temporal, el hipocampo y otras partes del cerebro. Sus efectos farmacol\u00f3gicos tienen m\u00faltiples objetivos. Adem\u00e1s de inhibir la actividad de la acetilcolinesterasa, tambi\u00e9n puede antagonizar el estr\u00e9s oxidativo y la apoptosis inducidos por el p\u00e9ptido \u03b2-amiloide (A\u03b2), el per\u00f3xido de hidr\u00f3geno y otras neurotoxinas, mediante la activaci\u00f3n de la v\u00eda de transducci\u00f3n de se\u00f1ales de la prote\u00edna quinasa C (PKC). La activaci\u00f3n de la \u03b1-secretasa promueve la descomposici\u00f3n de la prote\u00edna precursora \u03b2-amiloide (APP) de forma no amiloidog\u00e9nica para producir sAPP\u03b1, reduciendo la toxicidad mediada por A\u03b2, mientras que sAPP\u03b1 puede promover eficazmente la proliferaci\u00f3n celular, el crecimiento axonal y proteger los nervios. celular.<\/p>","protected":false},"featured_media":4172,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[22],"product_tag":[24],"class_list":{"0":"post-4102","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-daily-chemicals","7":"product_tag-daily-chemicals","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/product\/4102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/comments?post=4102"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/media\/4172"}],"wp:attachment":[{"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/media?parent=4102"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/product_brand?post=4102"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/product_cat?post=4102"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/chemneo.com\/es\/wp-json\/wp\/v2\/product_tag?post=4102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}