This article provides a comprehensive overview of Octocrylene USP Reference Material, CAS No. 6197-30-4. It delves into the chemical properties, uses, safety considerations, regulatory status, manufacturing process, and applications of this compound. The article aims to serve as a reference for professionals and students in the field of cosmetic and pharmaceutical sciences.
Octocrylene, with the CAS No. 6197-30-4, is a widely used UV filter in the cosmetic and pharmaceutical industries. It is known for its effectiveness in protecting skin from harmful ultraviolet (UV) radiation. This article aims to provide a detailed analysis of Octocrylene USP Reference Material, covering its various aspects to enhance understanding and awareness among the readers.
Octocrylene is a white to off-white crystalline solid that is odorless and stable under normal conditions. It has a molecular formula of C24H30O and a molecular weight of 338.47 g/mol. The compound consists of a benzophenone core with eight etilo groups attached to it. These ethyl groups contribute to its solubility in various organic solvents, making it suitable for use in a wide range of formulations.
The chemical structure of octocrylene allows it to absorb UV radiation in the range of 290 to 320 nm, effectively protecting the skin from UVA and UVB rays. This property makes it a valuable ingredient in sunscreens, skincare products, and other cosmetic applications.
Octocrylene is primarily used as a UV filter in sunscreens and skincare products. Its ability to absorb UV radiation makes it an effective ingredient in protecting the skin from sunburn and premature aging caused by UV exposure. Additionally, octocrylene is used in other cosmetic products such as lipsticks, foundations, and moisturizers to provide a broad-spectrum protection against UV rays.
In the pharmaceutical industry, octocrylene is used in ointments and creams to protect the skin from UV radiation during treatment. It is also employed in the formulation of ophthalmic preparations to prevent UV-induced damage to the eyes.
Octocrylene has been extensively evaluated for its safety profile. Regulatory agencies, such as the U.S. Food and Drug Administration (FDA) and the European Union's Scientific Committee on Consumer Safety (SCCS), have concluded that octocrylene is safe for use in cosmetic products when used within the recommended concentration limits.
However, some studies have suggested that octocrylene may be associated with skin irritation and allergic reactions in certain individuals. Therefore, it is crucial for manufacturers to conduct proper testing and labeling to ensure consumer safety.
Octocrylene is approved for use in cosmetic products by regulatory authorities worldwide. In the United States, it is classified as an over-the-counter (OTC) drug and is regulated under the FDA's OTC Drug Monograph. Similarly, in the European Union, octocrylene is included in the Positive List of UV Filters, which outlines the permitted use of UV filters in cosmetic products.
The regulatory status of octocrylene ensures that it meets the necessary safety and quality standards, making it a reliable ingredient for the cosmetic and pharmaceutical industries.
The manufacturing process of octocrylene involves the synthesis of benzophenone, which is then reacted with ethyl bromide to produce octocrylene. The reaction is typically carried out in an organic solvent, and the resulting product is purified through recrystallization or other purification techniques.
The manufacturing process is designed to ensure the production of high-purity octocrylene, which is essential for maintaining the quality and efficacy of products containing this compound.
Octocrylene finds extensive application in the cosmetic industry, particularly in sunscreens and skincare products. Its ability to provide broad-spectrum protection against UV rays makes it a valuable ingredient in these products. Additionally, octocrylene is used in hair care products, lipsticks, and other cosmetic formulations to protect the skin and hair from UV damage.
In the pharmaceutical industry, octocrylene is used in ointments, creams, and other topical preparations to protect the skin during treatment and to prevent UV-induced damage.
Octocrylene USP Reference Material, CAS No. 6197-30-4, is a crucial compound in the cosmetic and pharmaceutical industries. Its chemical properties, uses, safety considerations, regulatory status, manufacturing process, and applications have been thoroughly discussed in this article. Understanding these aspects is essential for professionals and students in the field to ensure the safe and effective use of octocrylene in various products.
Keywords: Octocrylene, CAS No. 6197-30-4, UV filter, sunscreen, cosmetic, pharmaceutical, safety, regulatory, manufacturing, application.
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