{"id":3821,"date":"2024-08-28T02:58:51","date_gmt":"2024-08-28T02:58:51","guid":{"rendered":"https:\/\/chemneo.com\/?post_type=product&p=3821"},"modified":"2024-08-28T02:59:34","modified_gmt":"2024-08-28T02:59:34","slug":"levodopa-cas59-92-7-2","status":"publish","type":"product","link":"https:\/\/chemneo.com\/pt\/product\/3821.html","title":{"rendered":"Levodopa CAS#59-92-7"},"content":{"rendered":"
\n\n\n\n
Levodopa Chemical Properties<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Melting point<\/td>\n276-278 \u00b0C (lit.)<\/span><\/td>\n<\/tr>\n
Ponto de ebuli\u00e7\u00e3o<\/td>\n334.28\u00b0C (rough estimate)<\/span><\/td>\n<\/tr>\n
alpha<\/td>\n-11.7 \u00ba (c=5.3, 1N HCl)<\/span><\/td>\n<\/tr>\n
densidade<\/td>\n1.3075 (rough estimate)<\/span><\/td>\n<\/tr>\n
\u00edndice de refra\u00e7\u00e3o<\/td>\n-12 \u00b0 (C=5, 1mol\/L HCl)<\/span><\/td>\n<\/tr>\n
storage temp.<\/td>\n2-8\u00b0C<\/span><\/td>\n<\/tr>\n
solubility<\/td>\nSlightly soluble in water, practically insoluble in ethanol (96 per cent). It is freely soluble in 1 M hydrochloric acid and sparingly soluble in 0.1 M hydrochloric acid .<\/span><\/td>\n<\/tr>\n
pka<\/td>\n2.32(at 25\u2103)<\/span><\/td>\n<\/tr>\n
forma<\/td>\nCrystalline Powder<\/span><\/td>\n<\/tr>\n
color<\/td>\nWhite to creamy<\/span><\/td>\n<\/tr>\n
Odor<\/td>\nat 100.00 %. odorless<\/span><\/td>\n<\/tr>\n
Odor Type<\/td>\nodorless<\/span><\/td>\n<\/tr>\n
Water Solubility<\/td>\nSlightly soluble in water, dilute hydrochloric acid and formic acid. Insoluble in ethanol.<\/span><\/td>\n<\/tr>\n
Merck<\/td>\n14,5464<\/span><\/td>\n<\/tr>\n
BRN<\/td>\n2215169<\/span><\/td>\n<\/tr>\n
Estabilidade:<\/td>\nStable. Incompatible with strong oxidizing agents. Light and air sensitive.<\/span><\/td>\n<\/tr>\n
InChIKey<\/td>\nWTDRDQBEARUVNC-LURJTMIESA-N<\/span><\/td>\n<\/tr>\n
LogP<\/td>\n-1.154 (est)<\/span><\/td>\n<\/tr>\n
CAS DataBase Reference<\/td>\n59-92-7(CAS DataBase Reference)<\/span><\/td>\n<\/tr>\n
NIST Chemistry Reference<\/td>\nLevodopa(59-92-7)<\/span><\/td>\n<\/tr>\n
Sistema de Registo de Subst\u00e2ncias da EPA<\/td>\nLevodopa (59-92-7)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n\n\n\n\n
<\/td>\n<\/tr>\n
Informa\u00e7\u00f5es de seguran\u00e7a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n\n
Hazard Codes<\/td>\nXn<\/span><\/td>\n<\/tr>\n
Risk Statements<\/td>\n22-36\/37\/38-20\/21\/22<\/span><\/td>\n<\/tr>\n
Safety Statements<\/td>\n26-36-24\/25<\/span><\/td>\n<\/tr>\n
WGK Germany<\/td>\n3<\/span><\/td>\n<\/tr>\n
RTECS<\/td>\nAY5600000<\/span><\/td>\n<\/tr>\n
F<\/td>\n10-23<\/span><\/td>\n<\/tr>\n
TSCA<\/td>\nYes<\/span><\/td>\n<\/tr>\n
HS Code<\/td>\n29225090<\/span><\/td>\n<\/tr>\n
Hazardous Substances Data<\/td>\n59-92-7(Hazardous Substances Data)<\/span><\/td>\n<\/tr>\n
Toxicidade<\/td>\nLD50 in mice (mg\/kg): 3650 \u00b1327 orally, 1140 \u00b166 i.p., 450 \u00b142 i.v., >400 s.c.; in male, female rats (mg\/kg): >3000, >3000 orally; 624, 663 i.p.; >1500, >1500 s.c. (Clark)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>","protected":false},"excerpt":{"rendered":"

A levodopa, tamb\u00e9m conhecida como L-DOPA ou 3,4-dihidroxi-L-fenilalanina, \u00e9 um amino\u00e1cido natural e um precursor essencial na bioss\u00edntese dos neurotransmissores dopamina, norepinefrina e epinefrina. Com a f\u00f3rmula molecular C9H11NO4, a levodopa \u00e9 um amino\u00e1cido grande e neutro que desempenha um papel significativo no tratamento da doen\u00e7a de Parkinson devido \u00e0 sua capacidade de atravessar a barreira hemato-encef\u00e1lica e ser convertida em dopamina.<\/p>\n

Quimicamente, a levodopa \u00e9 sintetizada a partir do amino\u00e1cido precursor tirosina atrav\u00e9s da a\u00e7\u00e3o da enzima tirosina hidroxilase. Como medicamento, a levodopa \u00e9 frequentemente formulada com um inibidor perif\u00e9rico da DOPA descarboxilase para reduzir a sua convers\u00e3o em dopamina fora do c\u00e9rebro, aumentando assim a sua efic\u00e1cia e reduzindo os efeitos secund\u00e1rios.<\/p>\n

A levodopa caracteriza-se pela sua efic\u00e1cia no al\u00edvio dos sintomas motores da doen\u00e7a de Parkinson, como tremores, rigidez e bradicinesia. \u00c9 normalmente administrada por via oral e absorvida pelo trato gastrointestinal, onde \u00e9 depois transportada para o c\u00e9rebro.<\/p>\n

Em resumo, a levodopa \u00e9 um composto farmac\u00eautico vital utilizado em neurologia pelo seu papel no tratamento da doen\u00e7a de Parkinson, repondo os n\u00edveis de dopamina no c\u00e9rebro. A sua administra\u00e7\u00e3o direcionada e a sua convers\u00e3o em dopamina fazem dela uma op\u00e7\u00e3o de tratamento essencial para gerir os sintomas motores associados a esta doen\u00e7a.<\/p>","protected":false},"featured_media":200,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[18],"product_tag":[19],"class_list":{"0":"post-3821","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-petroleum-additives","7":"product_tag-petroleum-additives","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/chemneo.com\/pt\/wp-json\/wp\/v2\/product\/3821","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chemneo.com\/pt\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/chemneo.com\/pt\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/chemneo.com\/pt\/wp-json\/wp\/v2\/comments?post=3821"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chemneo.com\/pt\/wp-json\/wp\/v2\/media\/200"}],"wp:attachment":[{"href":"https:\/\/chemneo.com\/pt\/wp-json\/wp\/v2\/media?parent=3821"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/chemneo.com\/pt\/wp-json\/wp\/v2\/product_brand?post=3821"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/chemneo.com\/pt\/wp-json\/wp\/v2\/product_cat?post=3821"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/chemneo.com\/pt\/wp-json\/wp\/v2\/product_tag?post=3821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}